GENERAL HISTOLOGY

Detailed explanation-1: -Osteoclastogenesis. Osteoclasts, the cells devoted to resorb the bone matrix, arise from the monocyte/macrophage lineage (34). They are multinucleated cells (from four up to twenty nuclei) formed by the fusion of mononuclear precursors (35).

Detailed explanation-2: -The osteoclasts are the mediators of the continuous destruction of bone. Osteoclasts occupy small depressions on the bone’s surface, called Howship lacunae; the lacunae are thought to be caused by erosion of the bone by the osteoclasts’ enzymes.

Detailed explanation-3: -Signals Promoting Bone Resorption One signal is the hormone parathyroid hormone (PTH), which gets released in response to a fall in the level of calcium in the extracellular fluid. PTH binds to receptors on osteoblasts and causes them to express a signal that stimulates the formation of osteoclasts.