GENERAL HISTOLOGY

Detailed explanation-1: -Chymotrypsin is a digestive enzyme that breaks down the protein in the small intestine. Precisely, it performs its function in the first part of the small intestine called the duodenum.

Detailed explanation-2: -Which of the following statements are true about the reactions at the active center of chymotrypsin? Explanation: Aspartate residue accepts a proton from serine.

Detailed explanation-3: -selectively cleaves (cuts) off pieces of amino acids from the protein chain. Specifically chymotrypsin cleaves phenylalanine, tyrosine, and tryptophan bonds, or in other words the aromatic amino acids. It cleaves these amino acids starting from the C-terminus of the protein.

Detailed explanation-4: -Chymotrypsin cleaves peptide bonds by attacking the unreactive carbonyl group with a powerful nucleophile, the serine 195 residue located in the active site of the enzyme, which briefly becomes covalently bonded to the substrate, forming an enzyme-substrate intermediate.