GENERAL HISTOLOGY

Detailed explanation-1: -Regulation and release of the thyroid hormones occurs as a negative feedback loop. What does this mean? In simple terms, a negative feedback loop means that as something increases, the production of whatever is causing the increase slows down.

Detailed explanation-2: -The hormones produced in the hypothalamus are corticotrophin-releasing hormone, dopamine, growth hormone-releasing hormone, somatostatin, gonadotrophin-releasing hormone and thyrotrophin-releasing hormone.

Detailed explanation-3: -The Thyroid Feedback Mechanism. TH regulates TRH gene expression and production through a negative feedback mechanism; TRH expression is high when TH levels are low, and TRH expression is suppressed when TH levels are increased. As outlined earlier, TRH expression is regulated by TH in the PVN (10, 61).

Detailed explanation-4: -Your hypothalamus releases thyrotropin-releasing hormone (TRH), which triggers your pituitary gland to release thyroid-stimulating hormone (TSH), which stimulates your thyroid to release T3 and T4.