GENERAL HISTOLOGY

Detailed explanation-1: -During bone resorption, the osteoclasts resorb the bone surface forming depressions known as Howship’s lacunae. Resorbing osteoclasts are highly polarized cells containing four structurally and functionally distinct membrane domains.

Detailed explanation-2: -Osteoclasts are the cells responsible for bone resorption. Located on bone surfaces, osteoclasts are large cells with as many as 50 nuclei. They secrete acids and hydrolytic enzymes that dissolve the bone matrix.

Detailed explanation-3: -Osteoclasts dissolve bone mineral by massive acid secretion and secrete specialized proteinases that degrade the organic matrix, mainly type I collagen, in this acidic milieu.