GENERAL HISTOLOGY

Detailed explanation-1: -Chondrocytes proliferate rapidly and secrete an extracellular matrix to form the cartilage model for bone. The cartilage model includes hyaline cartilage resembling the shape of the future bone as well as a surrounding membrane called the perichondrium.

Detailed explanation-2: -This type of cartilage has a glassy appearance when fresh, hence its name, as hyalos is greek for glassy. It looks slightly basophilic overall in H&E sections. Hyaline cartilage has widely dispersed fine collagen fibres (type II), which strengthen it. The collagen fibres are hard to see in sections.

Detailed explanation-3: -Before this time, the embryonic skeleton consists entirely of fibrous membranes and hyaline cartilage. The development of bone from fibrous membranes is called intramembranous ossification; development from hyaline cartilage is called endochondral ossification.

Detailed explanation-4: -In intramembranous ossification, bone develops directly from sheets of mesenchymal connective tissue. In endochondral ossification, bone develops by replacing hyaline cartilage. Activity in the epiphyseal plate enables bones to grow in length. Modeling allows bones to grow in diameter.