GENERAL HISTOLOGY

Detailed explanation-1: -The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth in several ways. It triggers chondrocyte proliferation in epiphyseal plates, resulting in the increasing length of long bones.

Detailed explanation-2: -Estrogen deficiency is associated with a gap between bone resorption and bone formation, likely due to the loss of the effects of estrogen on decreasing osteoblast apoptosis, oxidative stress, osteoblastic NF-B activity, and perhaps other, as yet undefined, mechanisms.

Detailed explanation-3: -Sex hormones (estrogen made in the ovary of females and testosterone made by the testes in males) control ability to reproduce. They also are a major reason that bone strength increases in the early teenage years. When teenagers have low estrogen or testosterone levels, the bone becomes weaker.