GENERAL HISTOLOGY

BONE

DEVELOPING BONE

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
When bone grows into pre-existing cartilage, the process is called
A
Osteoblastation
B
Primary Ossification
C
Endochondral Ossification
D
Intramenbranous Ossification
Explanation: 

Detailed explanation-1: -This process involves the replacement of hyaline cartilage with bone. It begins when mesoderm-derived mesenchymal cells differentiate into chondrocytes. Chondrocytes proliferate rapidly and secrete an extracellular matrix to form the cartilage model for bone.

Detailed explanation-2: -During endochondral ossification, an avascular tissue (cartilage) is gradually converted into one of the most highly vascularized tissues in the vertebrate body (bone). This conversion is dependent upon an angiogenic switch along the growth plate.

Detailed explanation-3: -Endochondral ossification is the mechanism responsible for the formation of all long bones of the axial skeleton (vertebrae and ribs) and the appendicular skeleton (limbs).

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