GENERAL HISTOLOGY

Detailed explanation-1: -Calcitonin Induces Bone Formation by Increasing Expression of Wnt10b in Osteoclasts in Ovariectomy-Induced Osteoporotic Rats. Calcitonin is a small peptide hormone secreted from the parafollicular cells of the thyroid gland in response to an increase in serum calcium.

Detailed explanation-2: -Parathyroid hormone (PTH) paradoxically causes net bone loss (resorption) when administered in a continuous fashion, and net bone formation (deposition) when administered intermittently.

Detailed explanation-3: -The present study provides evidence that calcitonin induces bone formation by increasing the expression of Wnt10b in osteoclasts and offers further information about the involvement of calcitonin in bone remodeling at the molecular level.

Detailed explanation-4: -The data show that calcitonin, because of its antiresorptive effects, can prevent bone loss after cessation of ovarian function. However, short-term treatment with calcitonin does not stimulate osteoblast activity; on the contrary, it exerts a negative effect on osteoblastic bone formation and mineralization.