GENERAL HISTOLOGY

Detailed explanation-1: -These proliferative areas become the epiphyseal plates (physeal plates/growth plates), which provide longitudinal growth of bones after birth and into early adulthood. After birth, this entire process repeats itself in the epiphyseal region; this is where the secondary ossification center forms [3].

Detailed explanation-2: -When babies are born, their bones are mostly cartilage, which is a soft and flexible substance. As babies grow, the cartilage in their bones grows. Over time and with a little help from calcium, bone replaces cartilage in a process known as ossification.

Detailed explanation-3: -The longitudinal growth of long bones continues until early adulthood at which time the chondrocytes in the epiphyseal plate stop proliferating and the epiphyseal plate transforms into the epiphyseal line as bone replaces the cartilage. Bones can increase in diameter even after longitudinal growth has stopped.

Detailed explanation-4: -The clavicle (collar bone), pictured here, is the last bone to complete growth, at about age 25. Measuring the length of long bones can give an estimate of age for children, but this technique is useful only until bones have stopped growing.