BONE
OSSIFICATION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Stage 1:Bone Collar Formation
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Stage 2:Cavitation
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Stage 3:Diaphysis Elongation
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Stage 4:Epiphyseal Ossification
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Detailed explanation-1: -This process involves the replacement of hyaline cartilage with bone. It begins when mesoderm-derived mesenchymal cells differentiate into chondrocytes. Chondrocytes proliferate rapidly and secrete an extracellular matrix to form the cartilage model for bone.
Detailed explanation-2: -Recent genetic evidence suggests that hypertrophic chondrocytes undergo a process of transdifferentiation to directly generate osteoblasts and osteocytes that contribute to the formation of trabecular and endocortical bone (Park et al., 2015; Yang et al., 2014b; Yang et al., 2014a; Zhou et al., 2014a).
Detailed explanation-3: -There are five phases in the bone remodeling process: ACTIVATION, RESORPTION, REVERSAL, FORMATION, and QUIESCENCE. The total process takes about 4 to 8 months, and occurs continually throughout our lives.
Detailed explanation-4: -The cartilage cells die out and are replaced by osteoblasts clustered in ossification centres. Bone formation proceeds outward from these centres. This replacement of cartilage by bone is known as endochondral ossification.