GENERAL HISTOLOGY

Detailed explanation-1: -Osteoclasts are the cells that degrade (resorb) bone during normal bone remodeling and in pathologic states in which bone resorption is increased.

Detailed explanation-2: -Osteoclasts Resorb Bone They closely attach to the bone matrix by binding its surface integrins to a bone protein called vitronectin. This close apposition seals off an area of the bone beneath the osteoclast and allows the osteoclast to form a microenvironment that resorbs bone.

Detailed explanation-3: -The osteoclasts remove bone by dissolving the mineral and breaking down the matrix in a process that is called bone resorption. The osteoclasts come from the same precursor cells in the bone marrow that produce white blood cells.

Detailed explanation-4: -OSTEOCLASTS are large cells that dissolve the bone. They come from the bone marrow and are related to white blood cells. They are formed from two or more cells that fuse together, so the osteoclasts usually have more than one nucleus. They are found on the surface of the bone mineral next to the dissolving bone.