GENERAL HISTOLOGY

Detailed explanation-1: -This process involves the replacement of hyaline cartilage with bone. It begins when mesoderm-derived mesenchymal cells differentiate into chondrocytes. Chondrocytes proliferate rapidly and secrete an extracellular matrix to form the cartilage model for bone.

Detailed explanation-2: -Endochondral ossification is the process of bone formation in which cartilage scaffolds, arranged in zones, are gradually replaced by bone. It occurs at the articular/epiphyseal and metaphyseal growth plates and at secondary centers of ossification, such as the carpal and tarsal bones.

Detailed explanation-3: -Endochondral ossification involves the replacement of hyaline cartilage with bony tissue. Most of the bones of the skeleton are formed in this manner. These bones are called endochondral bones. In this process, the future bones are first formed as hyaline cartilage models.

Detailed explanation-4: -In endochondral ossification, bone develops by replacing hyaline cartilage. Activity in the epiphyseal plate enables bones to grow in length (this is interstitial growth). Appositional growth allows bones to grow in diameter.