GENERAL HISTOLOGY

Detailed explanation-1: -PTH acts on the bone to increase blood calcium levels by stimulating osteoclasts to break down bone and release calcium into the bloodstream; on the GI tract to increase the activity of the enzyme in the intestines that activates vitamin D; and on the kidneys to promote calcium reabsorption.

Detailed explanation-2: -Parathyroid hormone (PTH), an important regulator of calcium homeostasis, targets most of its complex actions in bone to cells of the osteoblast lineage. Furthermore, PTH is known to stimulate osteoclastogenesis indirectly through activation of osteoblastic cells.

Detailed explanation-3: -Parathyroid hormone (PTH) stimulates bone resorption by acting directly on osteoblasts/stromal cells and then indirectly to increase differentiation and function of osteoclasts. PTH acting on osteoblasts/stromal cells increases collagenase gene transcription and synthesis.

Detailed explanation-4: -Parathyroid hormone regulates calcium levels in the blood, largely by increasing the levels when they are too low. It does this through its actions on the kidneys, bones and intestine: Bones – parathyroid hormone stimulates the release of calcium from large calcium stores in the bones into the bloodstream.