GENERAL HISTOLOGY

Detailed explanation-1: -Until adolescence, hyaline cartilage persists at the epiphyseal plate (growth plate), which is the region between the diaphysis and epiphysis that is responsible for the lengthwise growth of long bones (Figure 1).

Detailed explanation-2: -Epiphyseal plates cause the lengthwise growth of a long bone. By the end of puberty, when hor-mones inhibit long bone growth, epiphyseal plates have been completely replaced by bone, leaving only the epiphyseal lines to mark their previous location.

Detailed explanation-3: -Abstract. The epiphyseal growth plate is the main site of longitudinal growth of the long bones. At this site, cartilage is formed by the proliferation and hypertrophy of cells and synthesis of the typical extracellular matrix. The formed cartilage is then calcified, degraded, and replaced by osseous tissue.

Detailed explanation-4: -On the epiphyseal side of the epiphyseal plate, cartilage is formed. On the diaphyseal side, cartilage is ossified, allowing the diaphysis to grow in length. The metaphysis is the wide portion of a long bone between the epiphysis and the narrow diaphysis.

Detailed explanation-5: -The growth of the epiphyseal plate which adds to the length of bone is called interstitial growth. The epiphyseal plate is a plate of cartilage tissue that will grow in length, and will eventually be replaced by bone tissue.