GENERAL HISTOLOGY

Detailed explanation-1: -These osteoclast precursors (OCPs) are attracted to sites on bone surfaces destined for resorption and fuse with one another to form the multinucleated cells that resorb calcified matrixes under the influence of osteoblastic cells in bone marrow.

Detailed explanation-2: -Osteoclasts dissolve bone mineral by massive acid secretion and secrete specialized proteinases that degrade the organic matrix, mainly type I collagen, in this acidic milieu.

Detailed explanation-3: -Osteoclasts are large multinucleated cells whose function is to resorb bone. Osteoclasts dissolve the matrix and osteoid with acids and hydrolytic enzymes.

Detailed explanation-4: -The osteoclast disassembles and digests the composite of hydrated protein and mineral at a molecular level by secreting acid and a collagenase, a process known as bone resorption.