GENERAL HISTOLOGY

Detailed explanation-1: -During resorption the osteoclasts release local factors from the bone which result in two effects; inhibition of osteoclast function and stimulation of osteoblast activity. Finally, when the osteoclast completes its resorptive cycle, it secretes proteins that serve as a substrate for osteoblast attachment (58).

Detailed explanation-2: -Osteoclasts are multinucleated cells that are responsible for resorption of bone, and increased activity of these cells is associated with several common bone diseases, including postmenopausal osteoporosis.

Detailed explanation-3: -Osteoclasts are responsible for aged bone resorption and osteoblasts are responsible for new bone formation (Matsuoka et al., 2014). The resorption and formation is in stable at physiological conditions. However, when the balance is disturbed, bone architecture or function will be abnormal.

Detailed explanation-4: -Osteoclasts Resorb Bone The area of the osteoclast next to bone forms a “ruffled border” consisting of multiple infoldings of the osteoclast cell membrane. It secretes acid and proteases across the ruffled border, and these dissolve the mineral of bone and destroy the organic matrix (see Figure 9.8.