GENERAL HISTOLOGY

Detailed explanation-1: -This process involves the replacement of hyaline cartilage with bone. It begins when mesoderm-derived mesenchymal cells differentiate into chondrocytes. Chondrocytes proliferate rapidly and secrete an extracellular matrix to form the cartilage model for bone.

Detailed explanation-2: -Throughout childhood and adolescence, there remains a thin plate of hyaline cartilage between the diaphysis and epiphysis known as the growth or epiphyseal plate (Figure 6.4. 2f). Eventually, this hyaline cartilage will be removed and replaced by bone to become the epiphyseal line.

Detailed explanation-3: -Long bones have a thick outside layer of compact bone and an inner medullary cavity containing bone marrow. The ends of a long bone contain spongy bone and an epiphyseal line. The epiphyseal line is a remnant of an area that contained hyaline cartilage that grew during childhood to lengthen the bone.