GENERAL HISTOLOGY

Detailed explanation-1: -Osteoclasts are large multinucleated cells, with a ‘ruffled border’ that resorb bone matrix, as shown in the diagram above. They are important for remodelling, growth and repair of bone. (clast-greek ‘to break’). Osteoclasts are not derived from osteoprogenitor cells .

Detailed explanation-2: -Osteoclasts, the cells devoted to resorb the bone matrix, arise from the monocyte/macrophage lineage (34). They are multinucleated cells (from four up to twenty nuclei) formed by the fusion of mononuclear precursors (35).

Detailed explanation-3: -Osteoblasts are large, multinucleated cells that break down calcified bone matrix. c. Osteoblasts deposit bone matrix around themselves and become osteocytes when they are isolated in lacunae.