GENERAL HISTOLOGY

BONE

STRUCTURES

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
The cells responsible for making bone are
A
osteocytes
B
osteoblasts
C
osteoclasts
D
osteons
Explanation: 

Detailed explanation-1: -Osteoblasts are cells responsible for the secretion and deposition of bone morphogenetic proteins (BMPs) into the extracellular matrix during bone formation.

Detailed explanation-2: -Osteoblasts work in teams to build bone. They produce new bone called “osteoid” which is made of bone collagen and other protein. Then they control calcium and mineral deposition. They are found on the surface of the new bone.

Detailed explanation-3: -Osteoblasts are derived from mesenchymal stem cells (MSC). The commitment of MSC towards the osteoprogenitor lineage requires the expression of specific genes, following timely programmed steps, including the synthesis of bone morphogenetic proteins (BMPs) and members of the Wingless (Wnt) pathways [25].

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