GENERAL HISTOLOGY

Detailed explanation-1: -Bone remodeling is a highly complex process by which old bone is replaced by new bone, in a cycle comprised of three phases: (1) initiation of bone resorption by osteoclasts, (2) the transition (or reversal period) from resorption to new bone formation, and (3) the bone formation by osteoblasts [10, 11].

Detailed explanation-2: -The remodeling stage starts around 6 weeks after the injury. In this stage, regular bone replaces the hard callus. If you saw an X-ray of the healing bone, it would look uneven. But over the next few months, the bone is reshaped so that it goes back to looking the way it did before the injury.

Detailed explanation-3: -Bone remodelling relies on the correct function of two principal cells of the bone tissue: the osteoclasts, multinucleated cells that destroy the bone matrix, and the osteoblasts, having osteogenic functions.