GENERAL HISTOLOGY

Detailed explanation-1: -The increase in diameter is called appositional growth. Osteoblasts in the periosteum form compact bone around the external bone surface. At the same time, osteoclasts in the endosteum break down bone on the internal bone surface, around the medullary cavity.

Detailed explanation-2: -During appositional growth, osteoclasts resorb old bone that lines the medullary cavity, while osteoblasts, via intramembranous ossification, produce new bone tissue beneath the periosteum. Mesenchymal stem cell migration and differentiation are two important physiological processes in bone formation.

Detailed explanation-3: -Appositional growth occurs at the diaphysis of the long bone and the vertebral bodies, which changes the bone shape and increases its width [19, 22, 23]. During appositional growth of the long bones, width is added on the outside through the process of subperiosteal apposition.

Detailed explanation-4: -This increase in the length size of the bone is referred as interstitial growth whereas the increase in the preexisting diameter or width size of bones is referred as appositional growth.