GENERAL HISTOLOGY

Detailed explanation-1: -The direct conversion of mesenchymal tissue into bone is called intramembranous ossification. This process occurs primarily in the bones of the skull. In other cases, the mesenchymal cells differentiate into cartilage, and this cartilage is later replaced by bone.

Detailed explanation-2: -During the process of intramembranous ossification (also referred to as desmal ossification) mesenchymal cells differentiate into osteoblasts, which directly start to deposit bone. This mechanism generates the flat bones of the skull and the lateral clavicles.

Detailed explanation-3: -During intramembranous ossification, embryonic connective tissue called mesenchyme is replaced with bone. Intramembranous ossification occurs in: skull bones.