GENERAL HISTOLOGY

Detailed explanation-1: -Brown adipose tissue (BAT) contributes to non-shivering thermogenesis and plays an important role in the control of body temperature [4, 5, 10]. The thermogenic function of BAT is mediated by uncoupling protein 1 (UCP1), which is located in the mitochondrial inner membranes of brown adipocytes.

Detailed explanation-2: -White fat stores energy as large fat droplets, while brown fat has much smaller droplets and is specialized to burn them, yielding heat. Brown fat cells are packed with energy generating powerhouses called mitochondria that contain iron-which gives them their brown color.

Detailed explanation-3: -Brown fat: Brown fat is smaller than white fat. It stores energy and burns that energy to regulate your body temperature. Brown fat helps you burn calories by creating heat right before your body starts to shiver (thermogenesis). It also helps regulate sugar (glucose) and fat metabolism.

Detailed explanation-4: -BAT is regulated by environmental and nutritional factors that are mediated by neural and endocrine mechanisms. Some of these factors control the thermogenic activity, others regulate BAT mass and some may affect both processes.

Detailed explanation-5: -Recent studies have focused on the role of mitochondria in brown adipocytes that promotes energy consumption via adaptive thermogenesis [62]. Activation of mitochondria in brown adipocytes accelerates heat generation by increasing the inner mitochondrial membrane UCP1 [30].