GENERAL HISTOLOGY

Detailed explanation-1: -Osteoblasts are bone-forming cell, osteoclasts resorb or break down bone, and osteocytes are mature bone cells. An equilibrium between osteoblasts and osteoclasts maintains bone tissue.

Detailed explanation-2: -Osteoblasts are the cells that synthesize bone matrix proteins and are active in bone matrix mineralization. Bone matrix (also known as osteoid) consists of about 33% organic matter (mostly Type I collagen) and 67% inorganic matter (calcium phosphate, mostly hydroxyapatite crystals).

Detailed explanation-3: -The ground substance is the nonfibrillar organic component of the bone matrix and it fills the space around the collagen fibrils and hydroxyapatite crystals. The ground substance contains glycoproteins, proteoglycans, and glycosaminoglycans.

Detailed explanation-4: -Osteoblasts are cells responsible for the secretion and deposition of bone morphogenetic proteins (BMPs) into the extracellular matrix during bone formation.

Detailed explanation-5: -Osteocytes are derived from mesenchymal stem cells through osteoblast differentiation. Their entrapment within the bone matrix is possibly an active process and an embedment in neighbor osteoid forming osteoblasts (Bonewald, 2011).