GENERAL HISTOLOGY

Detailed explanation-1: -A mast cell is derived from the myeloid stem cell. It is a part of the immune and neuroimmune systems and contains many granules rich in histamine and heparin.

Detailed explanation-2: -All mammals produce heparin, a negatively charged glycosaminoglycan that is a major constituent of the secretory granules of mast cells which are found in the peritoneal cavity and most connective tissues.

Detailed explanation-3: -Mast cells granules, also called secretory lysosomes, contain both lysosomal proteins such as acid hydrolases, e.g., -hexosaminidase, as well as mediators such as histamine, and can secrete both together.

Detailed explanation-4: -A mast cell (also known as a mastocyte or a labrocyte) is a resident cell of connective tissue that contains many granules rich in histamine and heparin. Specifically, it is a type of granulocyte derived from the myeloid stem cell that is a part of the immune and neuroimmune systems.

Detailed explanation-5: -Heparin, derived from the mast cells of human lungs is responsible for the generation of kinins in allergic reactions due to the activation of the contact system. Int Arch Allergy Immunol.