GENERAL HISTOLOGY

Detailed explanation-1: -When mast cells are activated by an allergen that binds to serum IgE attached to their FcɛRI receptors, they release cytokines, eicosanoids and their secretory granules.

Detailed explanation-2: -Most commonly the receptors on the mast cells are TLRs and receptors for complement. Once the antigen binds to the receptors on the mast cell, it causes the release of inflammatory mediators, which helps to eliminate the pathogen that activated it.

Detailed explanation-3: -When mast cells detect a substance that triggers an allergic reaction (an allergen), they release histamine and other chemicals into the bloodstream. Histamine makes the blood vessels expand and the surrounding skin itchy and swollen. It can also create a build-up of mucus in the airways, which become narrower.

Detailed explanation-4: -Your body produces the chemical histamine, which causes the blood vessels in the area to expand, leading to swelling of the skin. Substances known to trigger allergic angioedema include: certain types of food – particularly nuts, shellfish, milk and eggs.