GENERAL HISTOLOGY

CONNECTIVE TISSUE GLAND

CONNECTIVE TISSUE

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
Macrophages perform the following functions ____
A
maintain local homeostasis of connective tissue
B
produce immunoglobulins
C
synthesis and secretion of the intercellular substance
D
participate in the energy production and water metabolism
E
deliver antigens to lymphocytes
Explanation: 

Detailed explanation-1: -Lymphocytes are immune cells found in the blood and lymph tissue. T and B lymphocytes are the two main types. Macrophages are large white blood cells that reside in tissues that specialize in engulfing and digesting cellular debris, pathogens and other foreign substances in the body.

Detailed explanation-2: -Macrophages are tissue-resident or infiltrated immune cells critical for innate immunity, normal tissue development, homeostasis, and repair of damaged tissue.

Detailed explanation-3: -Macrophages are specialised cells involved in the detection, phagocytosis and destruction of bacteria and other harmful organisms. In addition, they can also present antigens to T cells and initiate inflammation by releasing molecules (known as cytokines) that activate other cells.

Detailed explanation-4: -Macrophages identify and present foreign antigens in classes I and II major histocompatibility complexes (MHC) to T cells, which recognize the MHC-antigen complex through their T cell receptor. This initial step is all in vain if additional costimulatory and cytokine signaling does not occur concurrently.

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