GENERAL HISTOLOGY

Detailed explanation-1: -The differentiation and maturation of neutrophils are complex processes which take around 14 days in the bone marrow [33]. Despite this, neutrophils have a very short life-span in blood circulation, estimated to be less than 24 h [14].

Detailed explanation-2: -Under homeostatic conditions, neutrophils enter the circulation, migrate to tissues, where they complete their functions, and finally are eliminated by macrophages, all in the lapse of a day.

Detailed explanation-3: -Traditionally, neutrophils are considered short-lived cells. Once in the blood, neutrophils present a short circulating half-life of 6–8 h in humans and mice, based on ex vivo labelling of neutrophils and then following their fate in vivo.

Detailed explanation-4: -Neutrophils constitute 90% of circulating granulocytes and spend only 6 to 8 hours of their average 4-day life in circulation (the remainder in tissues). Effective antibacterial activity depends on the ability of neutrophils to travel to sites of infection, a process known aschemotaxis.