GENERAL HISTOLOGY

Detailed explanation-1: -Bone is made up of compact tissue (the hard, outer layer) and cancellous tissue (the spongy, inner layer that contains red marrow). Bone tissue is maintained by bone-forming cells called osteoblasts and cells that break down bone called osteoclasts.

Detailed explanation-2: -Osteoclasts are the cells that degrade bone to initiate normal bone remodeling and mediate bone loss in pathologic conditions by increasing their resorptive activity. They are derived from precursors in the myeloid/monocyte lineage that circulate in the blood after their formation in the bone marrow.

Detailed explanation-3: -Bone is an active living tissue that is constantly being renewed through a process known as remodelling. Cells called osteoclasts break down old, damaged bone to make way for new bone laid down by cells called osteoblasts.

Detailed explanation-4: -An osteoclast is a specialized cell that absorbs and removes bone, allowing for the development of new bone and maintenance of bone strength.

Detailed explanation-5: -The osteoclasts remove bone by dissolving the mineral and breaking down the matrix in a process that is called bone resorption. The osteoclasts come from the same precursor cells in the bone marrow that produce white blood cells.