GENERAL HISTOLOGY

Detailed explanation-1: -Bone. Bone is the tissue that comprises the body skeleton. Like all connective tissues, bone is composed of cells within an extracellular matrix of fibers (predominantly collagen type 1) and ground substance. The extracellular bone matrix is mineralized and arranged in circular layers called lamellae.

Detailed explanation-2: -Connective tissue consists of cells embedded in an extracellular matrix. The matrix, in turn, consists of fibers and ground substance.

Detailed explanation-3: -The connective tissues non cellular portion is known as the extracellular matrix (ECM), giving the physical scaffolding for the cells. The ECM is able to hold water, provide appropriate hydration of the tissue and form part of a selective barrier to the external environment.

Detailed explanation-4: -The extracellular matrix (ECM) is a complex network of both structural and functional proteins assembled in unique tissue-specific architectures. The ECM provides both a mechanical framework for each tissue and organ and an inductive substrate for cell signaling.