GENERAL HISTOLOGY

Detailed explanation-1: -Mast Cells are found close to small blood vessels in loose connective tissue. They contain large secretory granules of heparin proteoglycan-a weak anticoagulant. They also contain histamine, which promotes an inflammatory reaction when secreted.

Detailed explanation-2: -The cytoplasm of the mast cell contains 50–200 large granules that store inflammatory mediators, including histamine, heparin, a variety of cytokines, chondroitin sulfate, and neutral proteases (1).

Detailed explanation-3: -A type of white blood cell that is found in connective tissues all through the body, especially under the skin, near blood vessels and lymph vessels, in nerves, and in the lungs and intestines.

Detailed explanation-4: -The IgE-primed mast cell releases granules and powerful chemical mediators, such as histamine, cytokines, granulocyte macrophage colony-stimulating factor (GM-CSF), leukotrienes, heparin, and many proteases into the environment. These chemical mediators cause the characteristic symptoms of allergy.