GENERAL HISTOLOGY

Detailed explanation-1: -Mast cells They’re an important part of the immune system and help fight infection. When mast cells detect a substance that triggers an allergic reaction (an allergen), they release histamine and other chemicals into the bloodstream. Histamine makes the blood vessels expand and the surrounding skin itchy and swollen.

Detailed explanation-2: -Mast cells are an important source of heparin, which contributes to the morphology and storage capacity of their secretory granules (27). In vivo, this proteoglycan is exclusively synthesized in mast cells (28).

Detailed explanation-3: -Heparin, well known anticoagulant, can also modulate inflammatory and immunologic processes. Some investigators suggest that heparin inhibits mast cell degranulation. Mast cells play very important role in early phase of asthmatic reaction, releasing many proinflammatory mediators including histamine.

Detailed explanation-4: -Heparin is a naturally occurring glycosaminoglycan produced in the body by basophils and mast cells (image).