GENERAL HISTOLOGY

Detailed explanation-1: -Mast cells release mediators that increase both leukocyte adhesion to the venular endothelium and vascular permeability during reperfusion (47). These effects are mediated by various substances released by mast cells, such as histamine, tryptase, and chymase (46).

Detailed explanation-2: -Mast cells play an important role in how the immune system responds to certain bacteria and parasites and they help control other types of immune responses. They contain chemicals such as histamine, heparin, cytokines, and growth factors.

Detailed explanation-3: -A mast cell contains many granules rich in histamine and heparin. Mast cells are located in connective tissue, including the lung, skin, the linings of the stomach and intestine, and other sites.

Detailed explanation-4: -The inflammatory mediators increase the permeability of the blood vessels so that the immune cells can move from the blood stream to the affected tissue. After degranulation, mast cells resynthesize the mediators and repopulate granules (8).

Detailed explanation-5: -Mast cells are key players in the inflammatory response as they can be activated to release a wide variety of inflammatory mediators, by many different antigens including allergens, pathogens and physiological mediators.