GENERAL HISTOLOGY

Detailed explanation-1: -Mast cells are multifunctional bone marrow-derived tissue-dwelling cells that are the major producer of histamine in the body.

Detailed explanation-2: -Mast cells and basophils represent the most relevant source of histamine in the immune system. Histamine is stored in cytoplasmic granules along with other amines (e.g., serotonin), proteases, proteoglycans, cytokines/chemokines, and angiogenic factors and rapidly released upon triggering with a variety of stimuli.

Detailed explanation-3: -Mast cells are immune cells derived from the myeloid lineage. After arising in the bone marrow, progenitor cells circulate and become home to various tissues. Under the influence of stem cell factors locally produced by many cells in the tissue, the progenitor differentiates into a mature mast cell.

Detailed explanation-4: -Histamine is the most important mediator released from the mast cell involved with an allergic response. Histamine is derived from the amino acid histidine and works through three different receptors (H1, H2, H3). Stimulation of H1 receptors by the binding of histamine induces the classic allergic reaction.

Detailed explanation-5: -Mast cells are allergy cells responsible for immediate allergic reactions. They cause allergic symptoms by releasing products called “mediators” stored inside them or made by them.