GENERAL HISTOLOGY

Detailed explanation-1: -Basophils are 12 to15 µm in diameter, have bi-lobed or S-shaped nuclei, and contain cytoplasmic specific granules (0.5 µm) in diameter that stain blue to purple. The basophilia of the granules is due to the presence of heparin and sulfated glycosaminoglycans. These cells have similar functions as mast cells.

Detailed explanation-2: -Mast cells are very similar to basophil granulocytes (a class of white blood cells) in blood. Both are granulated cells that contain histamine and heparin, an anticoagulant. Their nuclei differ in that the basophil nucleus is lobated while the mast cell nucleus is round.

Detailed explanation-3: -Mast cells and basophil cells are both types of white blood cells that target allergic reactions. Mast cells are oblong shaped and basophil cells are spherical. Both cells contain a nucleus and granulocytes.

Detailed explanation-4: -Mast cells and basophils have similar morphological characteristics and express the high-affinity FceRI on their cell surface. Mast cells controlled IgE-dependent acute allergic responses. Basophils controlled IgE-mediated chronic responses, including IgE-mediated chronic allergic inflammation (IgE-CAI).

Detailed explanation-5: -Activated basophils and mast cells release both overlapping and unique sets of inflammatory mediators, including histamine, proteoglycans, lipid mediators, proteases, chemokines, growth factors and cytokines [9].