GENERAL HISTOLOGY

Detailed explanation-1: -Pepsin is a stomach enzyme that serves to digest proteins found in ingested food. Gastric chief cells secrete pepsin as an inactive zymogen called pepsinogen. Parietal cells within the stomach lining secrete hydrochloric acid that lowers the pH of the stomach. A low pH (1.5 to 2) activates pepsin.

Detailed explanation-2: -Trypsin and pepsin are both protease enzymes. Protease enzymes break other proteins down into small pieces. That’s why they are both found in the digestive system! They help digest the proteins found in the food we eat.

Detailed explanation-3: -The enzyme pepsin plays an important role in the digestion of proteins by breaking down the intact protein to peptides, which are short chains of four to nine amino acids. In the duodenum, other enzymes-trypsin, elastase, and chymotrypsin-act on the peptides reducing them to smaller peptides.

Detailed explanation-4: -The main digestive action of gastric juice is exerted by pepsin, which catalyzes the partial hydrolysis of proteins. Pepsin is secreted in the state of pepsinogen by glands in the stomach’s body and fundus. Pepsinogen (42.5 kDa) is a proenzyme, or zymogen, activated by H+ ions in gastric secretions.