GENERAL HISTOLOGY

Detailed explanation-1: -GH directly and through IGF-I stimulates osteoblast proliferation and activity, promoting bone formation. It also stimulates osteoclast differentiation and activity, promoting bone resorption. The result is an increase in the overall rate of bone remodeling, with a net effect of bone accumulation.

Detailed explanation-2: -Growth hormone fuels childhood growth and helps maintain tissues and organs throughout life. It’s produced by the pea-sized pituitary gland-located at the base of the brain. Beginning in middle age, however, the pituitary gland slowly reduces the amount of growth hormone it produces.

Detailed explanation-3: -The growth hormone/IGF-1 system stimulates both the bone-resorbing and bone-forming cells, but the dominant effect is on bone formation, thus resulting in an increase in bone mass. Thyroid hormones increase the energy production of all body cells, including bone cells.

Detailed explanation-4: -In children, GH has growth-promoting effects on the body. It stimulates the secretion of somatomedins from the liver, which are a family of insulin-like growth factor (IGF) hormones. These, along with GH and thyroid hormone, stimulate linear skeletal growth in children.

Detailed explanation-5: -Human growth hormone (hGH or GH) is a protein produced in the body that’s important not only during childhood but also throughout adulthood. Growth hormone is produced by the pituitary gland, which is known as the “master gland” because it secretes many hormones that control the actions of other glands.