GENERAL HISTOLOGY

Detailed explanation-1: -Cushing’s syndrome results from chronic exposure to excessive circulating levels of glucocorticoids. Cushing’s disease is the most common cause of endogenous hypercortisolism.

Detailed explanation-2: -Too much cortisol can cause some of the hallmark signs of Cushing syndrome-a fatty hump between your shoulders, a rounded face, and pink or purple stretch marks on your skin. Cushing syndrome can also result in high blood pressure, bone loss and, on occasion, type 2 diabetes.

Detailed explanation-3: -Addison’s disease happens when your body doesn’t have enough cortisol (and aldosterone), whereas Cushing’s syndrome happens when your body has too much cortisol (hypercortisolism).

Detailed explanation-4: -Cushing’s disease is a serious condition of an excess of the steroid hormone cortisol in the blood level caused by a pituitary tumor secreting adrenocorticotropic hormone (ACTH).

Detailed explanation-5: -Cushing disease is caused by an increase in the hormone cortisol, which helps maintain blood sugar levels, protects the body from stress, and stops (suppresses) inflammation. Cortisol is produced by the adrenal glands, which are small glands located at the top of each kidney.