GENERAL HISTOLOGY

Detailed explanation-1: -When one of the parathyroid glands is overactive (hyperparathyroidism) the parathyroid tumor makes too much PTH hormone which then causes our bones to release calcium constantly into the blood stream. This causes the bones to lose their density and hardness (it is the calcium that makes them hard).

Detailed explanation-2: -In primary hyperparathyroidism, one or more of the parathyroid glands is overactive. As a result, the gland makes too much parathyroid hormone (PTH). Too much PTH causes calcium levels in your blood to rise too high, which can lead to health problems such as bone thinning and kidney stones.

Detailed explanation-3: -Complications of hyperparathyroidism are mainly related to the long-term effect of too little calcium in your bones and too much calcium in your bloodstream. Common complications include: Osteoporosis. The loss of calcium from bones often results in weak, brittle bones that break easily (osteoporosis).

Detailed explanation-4: -Parathyroid hormone is directly involved in the bones, kidneys, and small intestine. In the bones, PTH stimulates the release of calcium in an indirect process through osteoclasts which ultimately leads to the resorption of the bones.