GENERAL HISTOLOGY

Detailed explanation-1: -1. A nonsteroid hormone binds to receptors on the cell membrane. 2. The binding of the hormone activates enzymes on the inner surface of the cell membrane.

Detailed explanation-2: -Non-steroid hormones are made of amino acids. They are not fat soluble, so they cannot diffuse across the plasma membrane of target cells. Instead, a non-steroid hormone binds to a receptor on the cell membrane. The binding of the hormone triggers an enzyme inside the cell membrane.

Detailed explanation-3: -Most water-soluble hormones such as glycoproteins and peptides combine with a receptor present on the plasma membrane because they are not lipid soluble and cannot move through the phospholipid cell membrane. As these hormone binds to their receptor, a cascade of reactions is triggered within the cytoplasm of the cell.

Detailed explanation-4: -Receptors for steroid and thyroid hormones are located inside target cells, in the cytoplasm or nucleus, and function as ligand-dependent transcription factors. That is to say, the hormone-receptor complex binds to promoter regions of responsive genes and stimulate or sometimes inhibit transcription from those genes.