GENERAL HISTOLOGY

Detailed explanation-1: -Without enough insulin, glucose builds up in the bloodstream instead of going into the cells. This buildup of glucose in the blood is called hyperglycemia. The body is unable to use the glucose for energy. This leads to the symptoms of type 1 diabetes.

Detailed explanation-2: -A lot of blood sugar enters the bloodstream. The pancreas pumps out more insulin to get blood sugar into cells. Over time, cells stop responding to all that insulin-they’ve become insulin resistant. The pancreas keeps making more insulin to try to make cells respond.

Detailed explanation-3: -Insulin resistance, also known as impaired insulin sensitivity, happens when cells in your muscles, fat and liver don’t respond as they should to insulin, a hormone your pancreas makes that’s essential for life and regulating blood glucose (sugar) levels.

Detailed explanation-4: -The insulin receptor is a member of the ligand-activated receptor and tyrosine kinase family of transmembrane signaling proteins that collectively are fundamentally important regulators of cell differentiation, growth, and metabolism.