GENERAL HISTOLOGY

Detailed explanation-1: -With type 1 diabetes, beta cells produce little or no insulin. Without enough insulin, glucose builds up in the bloodstream instead of going into the cells.

Detailed explanation-2: -People with type 1 diabetes have absent or malfunctioning beta cells so the hormones insulin and amylin are missing and the hormone GLP1 cannot work properly. This may explain, in part, why individuals with diabetes do not suppress glucagon during a meal and have high blood sugars after a meal.

Detailed explanation-3: -If you have type 1 diabetes, your pancreas doesn’t make insulin or makes very little insulin. Insulin helps blood sugar enter the cells in your body for use as energy. Without insulin, blood sugar can’t get into cells and builds up in the bloodstream.

Detailed explanation-4: -Type 1 diabetes is a disease in which autoimmune destruction of pancreatic -cells leads to insulin deficiency. Controlling blood glucose with an acceptable range is a major goal of therapy.