GENERAL HISTOLOGY

Detailed explanation-1: -In one category, type 1 diabetes, the cause is an absolute deficiency of insulin secretion. Individuals at increased risk of developing this type of diabetes can often be identified by serological evidence of an autoimmune pathologic process occurring in the pancreatic islets and by genetic markers.

Detailed explanation-2: -Type 2 Diabetes Mellitus (T2DM), one of the most common metabolic disorders, is caused by a combination of two primary factors: defective insulin secretion by pancreatic -cells and the inability of insulin-sensitive tissues to respond appropriately to insulin.

Detailed explanation-3: -In diabetes type 1, the pancreas does not make insulin, because the body’s immune system attacks the islet cells in the pancreas that make insulin. In diabetes type 2, the pancreas makes less insulin than used to, and your body becomes resistant to insulin.