GENERAL HISTOLOGY

Detailed explanation-1: -Presenting signs and symptoms of Addison’s disease include weakness, fatigue, anorexia, and skin pigmentation with hypotension, hyponatremia, and hyperkalemia. Acute adrenal crisis is a life-threatening presentation of Addison’s disease seen in as many as 25% of the patients [3].

Detailed explanation-2: -Hyperkalemia in Addison’s disease is mediated mainly by hypoaldosteronism, and thus a deficiency of aldosterone will result in potassium retention, through its inability to excrete potassium in the urine [7].

Detailed explanation-3: -Addisonian pigmentation of buccal mucosa Laboratory tests showed persistent hypotonic hyponatremia (sodium: 125 mmol/L, serum osmolality: <275 mOsm/kg) and serum potassium levels in the upper range of normal: 5.5 mmol/L (normal range: 3.5-5.5 mmol/L).

Detailed explanation-4: -The disorder has been associated with irritability, depression, and poor concentration. Individuals with Addison’s disease may have cravings for salt or salty foods and low blood sugar (glucose) levels. Women with Addison’s disease may have irregular menstrual periods, lose body hair and have a decreased sexual drive.

Detailed explanation-5: -fatigue (lack of energy or motivation) lethargy (abnormal drowsiness or tiredness) muscle weakness. low mood (mild depression) or irritability. loss of appetite and unintentional weight loss. the need to urinate frequently. increased thirst. craving for salty foods.