GENERAL HISTOLOGY

Detailed explanation-1: -Oxytocin is a natural hormone that stimulates uterine contractions in childbirth and lactation after childbirth. It also affects aspects of human behavior and the male and female reproductive systems.

Detailed explanation-2: -Oxytocin contracts the uterus and promotes the progress of labour. A large oxytocin pulse occurs with the birth, and pulses continue afterwards, which help the new mother to birth the placenta, prevent bleeding, and warm her chest for skin-to-skin contact with her baby.

Detailed explanation-3: -The release of oxytocin from the posterior pituitary gland during labor is an example of positive feedback mechanism. Oxytocin stimulates the muscle contractions that push the baby through the birth canal. The release of oxytocin result in stronger or augmented contractions during labor.

Detailed explanation-4: -Oxytocin is released in response to activation of sensory nerves during labor, breastfeeding and sexual activity. In addition oxytocin is released in response to low intensity stimulation of the skin, e.g., in response to touch, stroking, warm temperature, etc.

Detailed explanation-5: -Because oxytocin induces contraction in the myometrium, both the activation and the inhibition of its receptor have long been targets in the management of dysfunctional and preterm labours, respectively. We discuss current and novel OTR agonists and antagonists and their use and potential benefit in obstetric practice.