GENERAL HISTOLOGY

Detailed explanation-1: -Insulin is secreted by the -cells of the pancreatic islets of Langerhans in response to elevation of the intracellular Ca2+ concentration ([Ca2+]i).

Detailed explanation-2: -Beta cells make the hormone insulin, which lowers the glucose level. In type 1 diabetes, the body’s immune system mistakenly destroys the beta cells. This causes the pancreas to lose the ability to make insulin.

Detailed explanation-3: -The pancreatic beta cells are endocrine cells that synthetize, store, and release insulin, the anti-hyperglycemic hormone that antagonizes glucagon, growth hormone, glucocorticosteroids, epinephrine, and other hyperglycemic hormones, to maintain circulating glucose concentrations within a narrow physiologic range.

Detailed explanation-4: -Beta cells are cells that make insulin, a hormone that controls the level of glucose (a type of sugar) in the blood. Beta cells are found in the pancreas within clusters of cells known as islets.