GENERAL HISTOLOGY

Detailed explanation-1: -Oral hypoglycemic drugs are used only in the treatment of type 2 diabetes which is a disorder involving resistance to secreted insulin. Type 1 diabetes involves a lack of insulin and requires insulin for treatment. There are now four classes of hypoglycemic drugs: Sulfonylureas.

Detailed explanation-2: -Diabetes treatment: Lowering blood sugar A medication may work by: Causing the pancreas to make and release more insulin. Limiting the liver’s ability to make and release sugar. Blocking the action of enzymes in the intestines that break down carbohydrates, slowing how quickly cells take in carbohydrates.

Detailed explanation-3: -Glimepiride is available as 1 mg, 2 mg, or 4 mg tablets, taken once a day with breakfast or twice a day with meals. For patients at increased risk for hypoglycemia, such as older patients or those with chronic kidney disease, the initial dose could be as low as 0.5 mg daily.

Detailed explanation-4: -They cause greater suppression of overnight hepatic glucose output, thereby lowering fasting blood glucose concentrations more; these benefits, however, may be counterbalanced by an increased risk of hypoglycemia. Sulfonylureas can be used as monotherapy, or in combination with other oral hypoglycemic drugs or insulin.