ENDOCRINE SYSTEM
ADRENAL
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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2
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FOR
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ZB
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4
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Detailed explanation-1: -The extracts of 6 tumors yielded an ACTH-like substance. Forty-three patients with Cushing’s disease (without pituitary tumor) had, before treatment, a mean ACTH level of 0.18 plus or minus 0.01 mU/100 ml, accompanied by high levels of plasma cortisol (32.1 plus or minus 1.9 mug/100 ml).
Detailed explanation-2: -Adrenal insufficiency is defined as baseline cortisol level of less than 15g/dL, or a change of less than 9g/dL after administration of 250g of adrenocorticotropic hormone (ACTH).
Detailed explanation-3: -Glucocorticoid excess in Cushing’s syndrome leads to complications such as increased visceral adipose tissue, obesity, impaired glucose tolerance, diabetes mellitus, hypertension, hyperlipidemia, osteoporosis, and neuropsychiatric comorbidities, and is associated with a significantly increased mortality [1–4].