GENERAL HISTOLOGY

ENDOCRINE SYSTEM

ADRENAL

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
The END-stage of the metabolites of NE+E are
A
VMA+HVA
B
VMA+E
C
HVA+NE
D
Non
Explanation: 

Detailed explanation-1: -Vanillic acid (VMA) is the major end product of human norepinephrine and epinephrine metabolism (64).

Detailed explanation-2: -Homovanillic acid (HVA) and vanillylmandelic acid (VMA) measurements in urine are used for screening children for catecholamine-secreting tumors such as neuroblastoma, pheochromocytoma, and other neural crest tumors and monitoring those who have had treatment for these tumors.

Detailed explanation-3: -Vanillylmandelic acid (VMA), a metabolic by-product of norepinephrine and epinephrine, can be used to detect neuroblastoma and other tumors of neural crest origin.

Detailed explanation-4: -The low HVA and VMA values suggest decreased sympathetic outflow contributing to reduced physical activity and severe obesity, especially in patients with a hypothalamic tumor.

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