GENERAL HISTOLOGY

Detailed explanation-1: -Thyroid hormones regulate growth by several mechanisms. In addition to their negative feedback effect on the stimulatory hormones thyrotropin-releasing hormone (TRH) and thyrotropin (TSH), thyroid hormones also regulate their receptors in various physiological and pathological conditions.

Detailed explanation-2: -Thyroxine controls how much energy your body uses (the metabolic rate). It’s also involved in digestion, how your heart and muscles work, brain development and bone health. When the thyroid gland does not make enough thyroxine (called hypothyroidism), many of the body’s functions slow down.

Detailed explanation-3: -Thyroid hormone is necessary for bone growth because of its direct effect on bone, because of the indirect effects of stimulating GH release from pituitary somatotrophs and thereby increasing the level of IGF-I, and because of effect with the tissue action of IGF-I (Fig. 1).

Detailed explanation-4: -Your hypothalamus releases thyrotropin-releasing hormone (TRH), which triggers your pituitary gland to release thyroid-stimulating hormone (TSH), which stimulates your thyroid to release T3 and T4.